"without vomiting."

Levels of dopamine appear to be depleted in the corpus striatum of these patients. They cannot be do by with dopamine because it does not cross the blood-brain barrier, but levodopa, the metabolic herald of dopamine, does.

Large doses of levodopa given(p) orally are rapidly decarboxylated to dopamine in extracerebral tissue so little of a given dose actually r separatelyes the central nervous system unchanged. The super doses needed for therapeutic effect are often tended to(p) by adverse effects such as sickness and other effects. Carbidopa inhibits the decarboxylation of levodopa peripherally, and does not cross the blood-brain barrier and does not bushel the metabolism of levodopa within the central nervous system. This reduces the incidence of nausea in patients requiring levodopa.

HOW SUPPLIED: Sinemet comes in tablets in tether strengths:

Sinemet 25-200 contains 25 mg carbidopa and 100 mg levodopa

Sinemet 10-100 contains 10 mg carbidopa and 100 mg levodopa

Sinemet 25-250 contains 25 mg carbidopa and 250 mg levodopa

DOSAGE: The optimum cursory dosage of Sinemet must be determined by titrating each patient. Initial dosage is usually one Sinemet 25-100 tablet leash times a day. This may be increase by one tablet a day or any other day as necessary until dosage of eight tablets a day of Sinemet 25-100 is reached. If Sinemet 10-100 is used, the dosage is initiated with one tablet three or four times a day, and dosage is increased by o

SIDE make: The most common adverse reactions with Sinemet are dyskinesia such as choreiform, dystonic and other involuntary movements, and nausea.

Other side effects describe have been: chest pain; asthenia; cardiac irregularities; hypotension; erect effects (orthostatic hypotension), hypertension; syncope; phlebitis; palpitation; dark spitting; gastrointestinal bleeding; development of duodenal ulcer; anorexia; vomit; diarrhea; constipation; dyspepsia; dry mouth; appreciation alterations; agranulocytosis; hemolytic and nonhemolytic anemia; thrombocytopenia; leukopenia; angioedema; urticaria; pruritus; Henoch-Schonlein purpurea; bullous lesions (including pemphigus-like reactions); tolerate pain; shoulder pain; muscle cramps; psychotic episodes including delusions, hallucinations and paranoiac ideation; neuroleptic malignant syndrome; bradykinetic episodes; confusion; agitation; dizziness; drowsiness; dream abnormalities including nightmares; insomnia; headache; paresthesia, depression with or without development of self-destructive tendencies; dementia; increased libido; dyspnea; upper respiratory transmittal; rash; increased sweating; alopecia; dark sweat; urinary tract infection; urinary frequency and dark urine. WARNINGS: Levodopa discourse must be
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